Your assignment is to prepare and submit a paper on pathophysiology and pharmacology.

Your assignment is to prepare and submit a paper on pathophysiology and pharmacology. This causes blood to accumulate compressing the brain. There are two types of haemorrhagic strokes. Which include intracerebral, and subarachnoid categorized based on the disease aetiology (Ewan et al. 2010).

Ischemic Cerebrovascular Accident is caused by the interruption of blood supply to the cerebral tissue. It has multiple etiologic mechanisms and clinical manifestations. The ischemia is caused by thrombosis, embolism, arterial luminal obliteration, venous congestion and systemic hypoperfusion (Laredo et al. 2011). An Ischemic thrombotic stroke is caused by the development of a clot that obstructs the blood vessel. Pathology in the local endothelium is the common trigger of thrombosis. The most common pathological feature of vascular obstruction is the chronic inflammation disease Atherosclerosis.

Atherosclerotic plaques usually form at bifurcation points of vessels and high shear stress points. They overexpress plasminogen activator inhibitor-1 that inhibits the enzyme plasminogen activator, which converts plasminogen to plasmin that degrades plasma proteins (Jorge et al. 2010). Plasmin is essential in fibrinolysis. Therefore, inhibition of activation promotes the formation of blood clots. Endothelial surface injury triggers an inflammatory reaction recruiting cytokines and peroxides. These substances trigger the expression of P-selectin, E-selectin and intercellular adhesion molecule-1 by the endothelial cells molecules necessary for the adhesion of recruited leukocytes to the endothelial wall. They migrate into the intima forming a fatty streak that are then infiltrated by macrophages forming plaques and accumulating lipids to form foam cells (Santos et al. 2012). Plaques can enlarge and occlude blood vessels, become ulcerated, calcify, develop thrombosis, form embolus or lead to the formation of an aneurysm.

Show more

Calculate Your Essay Price
(550 words)

Approximate price: $22

Calculate the price of your order

550 words
We'll send you the first draft for approval by September 11, 2018 at 10:52 AM
Total price:
The price is based on these factors:
Academic level
Number of pages
Basic features
  • Free title page and bibliography
  • Unlimited revisions
  • Plagiarism-free guarantee
  • Money-back guarantee
  • 24/7 support
On-demand options
  • Writer’s samples
  • Part-by-part delivery
  • Overnight delivery
  • Copies of used sources
  • Expert Proofreading
Paper format
  • 275 words per page
  • 12 pt Arial/Times New Roman
  • Double line spacing
  • Any citation style (APA, MLA, Chicago/Turabian, Harvard)

Our guarantees

Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.

Money-back guarantee

You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.

Read more

Zero-plagiarism guarantee

Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.

Read more

Free-revision policy

Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.

Read more

Privacy policy

Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.

Read more

Fair-cooperation guarantee

By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.

Read more

Order your essay today and save 10% with the coupon code: best10