Your assignment is to prepare and submit a paper on early phases of p53-enhanced apoptosis are reversible. These changes encompass the condensation of chromatin, nuclear blebbing, cytoplasmic, and the eventual demise of cellular without the loss of the membrane.
Over time, the field of apoptosis has received much attention and has become a major field of research. As the understanding of the way the process of apoptosis takes place, it has become easier to effectively define the manner in which the late and earlier phases of this process take place. The materialization of the phosphatidylserine (PS) starts from the inner to the outer parts of the cell membrane is one of the earliest features of the process of apoptosis. Those cells having PS on the outer surfaces may be linked so as to enhance the ease of identification as well as possible removal of phagocytes and cells. Another early feature of an apoptotic cell is the actual split of the genomic DNA into very large fragments of about 50-300 kb. There are so many cell types that show this kind of process, and they include U937 leukemia cells, thymocytes, and the MOLT-4 human T lymphoblastoid cells. Generally, it is assumed robust DNA fragments are as a result of a split of the looped domains at the attached points of the nuclear matrix, and they can occur independently. The tumor suppressor, p53 is the best example of a molecule that can result in an induction of the apoptosis process. This molecule is initiated by a myriad of changes to the cellular material, such as changed DNA, hypoxia, heat shock, as well as nucleotide depletion.
Until now, the mechanism upon which the Enhanced P53 apoptosis takes place is still not known well, but it is clear that the transcriptional activation of a variety of apoptosis-enhancing genes is involved. These kinds of genes include tax, fats, KILLER/DR5, and more others. On top of the role it plays in the induction of apoptosis, P53 is also responsible to enhance the process of DNA repair. Currently, it is believed that the apoptosis induction process is irreversible. According to the preliminary results from the laboratory, the process of DNA repair is normally enhanced very early in the p53- Enhanced apoptosis, and this early stage may actually be reversible. The current work is based on these early works, and through more evidence, it has confirmed that indeed the early phases of p53-Enhanced apoptosis can be reversed.
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