Hi, need to submit a 2000 words paper on the topic Genetic Factors Modulating Heroin Tolerance Capacity. By collecting blood samples from volunteers who are receiving methadone replacement therapy, this study aims to determine the role of opioid receptors (i.e. m, k and d ) that contributes to the mechanism of tolerance, drug resistance, and susceptibility to the drug. This study will benefit forensic toxicologists in enabling them to offer a more meaningful interpretation of a blood drug concentration found in heroin abuse cases.
.In line with this, the following research objectives will be considered in testing the research hypothesis: (1) determine the extent of variation opioid receptors in heroin-dependent volunteers who are receiving methadone therapy programme (0 – 9 months). (2) identify the functional consequences caused by genetic polymorphism (0 – 24 months). and (3) characterize the effects of methadone replacement therapy based on the levels of methadone replacement tolerance in each volunteer (0 – 36 months).
To determine the extent of phenotypic variation in opioid receptors and identify common genetic polymorphisms, Europeans with a history of heroin-dependent that is currently undergoing methadone replacement therapy programme will be invited to participate in this study. To assess the contribution of methadone replacement in the patterns of opioid receptor expression, the researcher will re-measure the key receptor levels after the 6th week of the methadone replacement period.
Aside from identifying volunteers with a responsive receptor to methadone replacement therapy, this approach will enable the researcher to minimize the potential confounding effect of habitual lifestyle on .phenotypically “high” and “low” expressers. Individuals with high or low levels of receptors and those with responsive phenotype will be classified under subgroups. Eventually, lymphocytes taken from the volunteers will be transformed using Epstein Barr Virus (EBV) to produce immortalized cell lines which will be used as a model system in studying the drug-gene interactions that could modulate opiate receptor levels. .
Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.
You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.Read more
Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.Read more
Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.Read more
Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.Read more
By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.Read more